The Incidence of Ototoxicity in Patients Using Iron Chelators

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The Incidence of Ototoxicity in Patients Using Iron Chelators.

OBJECTIVE In this study, we aimed to detect the incidences of ototoxicity in patients with hemoglobinopathies taking deferoxamine (DFO), deferiprone, and deferasirox using the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) scale to obtain more objective data. MATERIALS AND METHODS Fifty-five transfusion-dependent patients were evaluated in this study. T...

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The Incidence of Amikacin Ototoxicity in Multidrug-Resistant Tuberculosis Patients

Amikacin has been shown to irreversibly suppressCochlear activity.The aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.In this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (MDR-TB) were included.All patients received fixed dose of intravenous amikacin(500 mg...

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the incidence of amikacin ototoxicity in multidrug-resistant tuberculosis patients

amikacin has been shown to irreversibly suppresscochlear activity.the aim of this study is to assess the incidence of amikacinototoxicity in multidrug-resistant tuberculosis patients and riskfactors associated withthis ototoxicity.in this cross-sectional study, 41 patientswith multidrug-resistant tuberculosis (mdr-tb) were included.all patients received fixed dose of intravenous amikacin(500 mg...

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This study details the prevention of gentamicin-induced hearing loss in guinea pig in vivo. The approach is based on our recent demonstrations of a redox-active gentamicin-iron complex in vitro and partial attenuation of gentamicin-induced hearing loss by the iron chelators deferoxamine and 2,3-dihydroxybenzoate. In our study, guinea pigs receiving injections of gentamicin (120 mg/kg body weigh...

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ژورنال

عنوان ژورنال: The Journal of International Advanced Otology

سال: 2017

ISSN: 1308-7649,2148-3817

DOI: 10.5152/iao.2016.1852